Dr. Yang H. Yun


Dr. Daniel B. Sheffer
Dr. Yang H. Yun
 

Dr. Yang H. Yun
Associate Professor

Phone: 330-972-6619
Fax: 330-374-8834
Office: OLRC, 301D
E-mail: yy@uakron.edu
Website:

gozips.uakron.edu/~yy



  Education
Ph.D. in Engineering with Concentration in Biomedical Engineering, University of Memphis,1999
M.S. in Biomedical Engineering, University of Memphis, 1994
B.S. in Mechanical Engineering, Christian Brothers University, 1989

  Professional Honors and Societies
CAREER Award Recipient from the National Scientific Foundation (Award abstract at NSF web site)
Firestone Fellow, The University of Akron, Akron, OH
Scientific Advisory Board, IC-Medtech, Inc. San Diego, CA
Scientific Advisory Board, Center for Silver Therapeutics Research, The University of Akron, Akron, OH
Microscopy Society of Northeastern Ohio
Biomedical Engineering Society

  Research Interests
Biomaterials
Cancer Therapy
Drug and Gene Delivery
Electrospinning
Nanotechnology
Tissue Engineering
Treatment of Infectious Diseases

  In the News

  Patents
W. Chen, G. R. Gaudette, H. Jiang, A. S. Saltman, and Y. H. Yun, Biodegradable Polymer Device, US patent application number 10/364,877 filed on 8/12/04.

Y. H. Yun, A. Ditto, P. N. Shah, D. Sarkar and A. Sen Gupta Materials and Methods for Introducing Genetic Materials to Living Cells, US patent application number 60/859,436 filed on 11/16/08.

  Publications
P. N. Shah, J. Smolen, A. Sen Gupta, and Y. H. Yun, Electrospun pseudo poly(amino acids) for Tissue Engineering Applications, in Nanotechnology in Tissue Engineering and Regenerative Medicine, K. Popat (ed.) Boca Raton: CRC Press LLC. (Invited Book Chapter, Submitted).

Y. Cai, Y. H. Yun, and B. Z. Newby, Generation of Contact-printing Based Poly (ethylene glycol) Gradient Surfaces with Micrometer-sized Steps, Colloids and Surfaces B: Biointerfaces, vo. 75, p. 112-122, 2010. (doi: 10.1016/j.colsurfb.2009.08.023).

A. J. Ditto, P. N. Shah, and Y. H. Yun, Non-viral gene delivery using nanoparticles, Expert Opinion on Drug Delivery, vol. 6(11), p. 1-12, 2009, (doi: 10.1517/174252420903241796).

P. N. Shah, A. A. Puntel, S. T. Lopina, and Y. H. Yun, Development and in vitro cytotoxicity evaluation of a microparticle type drug delivery system for delivery of proteins using a novel L-tyrosine based polyphosphate polymer, Colloid and Polymer Science, vol. 287 (10), p.1195-12-5, 2009, (doi: 10.1007/s00396-009-2082-4).

P. N. Shah, S. T. Lopina, and Y. H. Yun, Blends of novel L-tyrosine based polyurethanes and polyphosphate for potential biomedical applications, Journal of Applied Polymer Science, vol. 114 (5), p. 3235-3247, 2009, (doi: 10.1002/app.30509).

A. J. Ditto, P. N. Shah, L. R. Gump and Y. H. Yun, Nanospheres Formulated from L-Tyrosine Polyphosphate Exhibiting Sustained Release of Polyplexes and In Vitro Controlled Transfection Properties, Molecular Pharmaceutics, vol.6 (3), p. 986-995, 2009, (doi: 10.1021/mp9000316).

K. M. Hindi, A. J. Ditto, D. A. Medvetz, M. J. Panzner, Y. H. Yun,* C. L. Cannon,* W. J. Youngs,* In Vitro and In Vivo Antimicrobial Efficacy of a Silver Carbene Complex (SCC10)-Encapsulated Nanospheres, Biomaterials, vol. 30, p.3771-3779, 2009, (doi: 10.1016/j.biomaterials.2009.03.044). *Co-last authors.

P. N. Shah, R. L. Manthe, S. T. Lopina, and Y. H. Yun, Electrospinning of L-tyrosine polyurethanes for potential biomedical applications, Polymer, vol. 50, 2281-2289, 2009, (doi: 10.1016/j.polymer.2009.02.048).

A. J. Ditto, P. N. Shah, S. T. Lopina, and Y. H. Yun, Nanospheres Formulated from L-Tyrosine Polyphosphate as a Potential Intracellular Delivery Device, International Journal of Pharmaceutics, vol. 368, 199-206, 2009 (doi: 10.1016/j.ijpharm.2008.10.019).

D. A. Medvetz, K. M. Hindi, M. J. Panzner, A. J. Ditto, Y. H. Yun and W. J. Youngs. Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived From 4,5-dichloro-1H-imidazole, Metal-Based Drugs, vol. 2008, 1-7, 2008 (doi: 10.1155/2008/384010).

E. U. Azeloglu,* Y. H. Yun,* A. E. Saltman, I. B. Krukenkamp, F. Chiang, and W. Chen, and G. R. Gaudette. High resolution mechanical function in the intact porcine heart: mechanical effects of pacemaker location, Journal of Biomechanics, vol. 39 (4), p. 717-725, (2006). *Co-first authors.

Y. H. Yun, R. Chan, H. Liang, and W. Chen, Sustained release of PEG-g-chitosan complexed DNA from poly(lactide-co-glycolide), Journal of Biomaterials Science. Polymer Edition, vol. 16 (11), p. 1359-1378, (2005).

Y. H. Yun, A. Kim, and W. Chen, The application of derivatized hyaluronan for non-viral gene therapy, Hyaluronan: Structure, Metabolism, Biological Activities, Therapeutic Applications, in Hyaluronan: Structure, Metabolism, Biological Activities, Therapeutic Applications, A. Balazs and V. C. Hascall (eds.) Matrix Biology Institute, p. 447-450, (2005).

A. Kim, P. Yellen, Y. H. Yun, E. U. Azeloglu, and W. Chen, Delivery of a hyaluronan synthase gene via a crosslinked hyaluronan film, Biomaterials, vol. 26 (13), p. 1585-1593, (2005).

Y. H. Yun and W. Chen, Microspheres formulated from native hyaluronan for applications in gene therapy, in Polymeric Gene Delivery: Principles and Applications, M. M. Amiji (ed.) Boca Raton: CRC Press LLC, p. 475-486, 2004.

Y. H. Yun, D. J. Goetz, P. Yellen, and W. Chen, Hyaluronan microspheres for sustained gene delivery and site specific targeting, Biomaterials, vol. 25 (1) p. 147-157, (2004).

V. S. Patil, C. J. Campbell, Y. H. Yun, S. M. Slack, and D. J. Goetz, Particle size influences adhesion under flow, Biophysical Journal, vol. 80(4), p. 1733-1743 (2001).

Y. H. Yun, V. T. Turitto, and J. I. Hochstein, Porous Media modeling of flow in aneurysms treated with metallic coils, Proceedings of the 1999 Heat Transfer Conference, HTD99-314, p. 1-11 (1999).

Y. H. Yun, V. T. Turitto, K. P. Daigle, P. Kovacs, J. A. Davidson, and S. M. Slack, Initial hemocompatibility studies of titanium and zirconium alloys: prekallikrein activation, fibrinogen adsorption, and their correlation with surface electrochemical properties, Journal of Biomedical Materials Research, vol. 32 (1), p. 77-85 (1996).

Y. H. Yun, S. M. Slack, K. P. Daigle, J. A. Davidson, and V. T. Turitto, Initial biocompatibility studies of novel titanium and zirconium alloys for cardiovascular applications, in Compatibility of Biomedical Implants, P. Kovacs and N. S. Istephanous (eds.) vol. 94(15), p. 105-115 (1994).

  Recent Presentations
A. J. Ditto, K.M. Hindi, M. J. Panzer, C. L. Cannon, W. J. Youngs, and Y. H. Yun Nanoparticles Loaded with Silver-Based Drugs as a Nebulizable Antimicrobial in the Chronically Infected Lungs of Cystic Fibrosis Patients, Annals of Biomedical Engineering, 2009.

A. J. Ditto, N. Robishaw, M. J. Panzer, P. N. Shah, W. J. Youngs, Y. H. Yun, Folate Targeted Degradable Nanoparticles as an Anticancer Therapeutic, Annals of Biomedical Engineering, 2009.

P. N. Shah, J. Smolen, Y. H. Yun, Electrospun Biodegradable L-tyrosine based Polyurethane Scaffolds for Biomedical Applications, Annals of Biomedical Engineering, 2009.

Y. H. Yun, The next generation of antimicrobial nanoparticles, 2nd Annual Meeting of the Center for Silver Therapeutics Research, 2009.

C. L. Cannon, D. S. Han, J. A. Taylor, C. E. Hovis, J. K. Hillard, A. J. Ditto, K. M. Hindi, M. J. Panzer, W. J. Youngs, and Y. H. Yun, Nebulized nanoparticles loaded with broad-spectrum silver-based antimicrobials for depot treatment of pulmonary infections, American Thoracic Society, (2009). American Thoracic Society has designated the subject of this abstract for a new release to journalists.

A. J. Ditto, P. N. Shah, and Y. H. Yun, Rapid biodegradable nanospheres designed for enhanced intracellular delivery of DNA, Annals of Biomedical Engineering, (2008).

P. N. Shah, S. T. Lopina, Y. H. Yun, Biocompatibility determination of novel L-tyrosine-based polyphosphates and polyurethanes. Microscopy Society of Northeast Ohio, (2008). Winner of the best poster competition for graduate student in biological science.

A. J. Ditto, S. T. Lopina, Y. H. Yun, Gene Therapy with Nanospheres, Microscopy Society of Northeast Ohio, (2008). Runner up of the best poster competition for a graduate student in biological science.

R. Manthe, P. N. Shah, and Y. H. Yun, Fabrication of nanofibrous membranes via electrospinning of novel L-tyrosine-based polyurethane, Microscopy Society of Northeast Ohio, (2008). Runner up of the best poster competition for an undergraduate student in biological science.

P. N. Shah, S. T. Lopina, Y. H. Yun, Biological characterization of novel L-tyrosine based polyphosphate and polyurethanes, American Institute of Chemical Engineers, National Conference, (2007).

P. N. Shah, S. T. Lopina, Y. H. Yun, Development and in vitro biocompatibility evaluation of a microparticle type drug delivery device for controlled delivery of therapeutic proteins using a novel L-tyrosine based polyphosphate, Society for Biomaterials, (2007).

P. N. Shah, S. T. Lopina, Y. H. Yun, Physico-chemical and Biological characterization of blends of L-tyrosine based polyurethanes and polyphosphate for biomedical applications, Society for Biomaterials, (2007).

P. N. Shah, S. T. Lopina, Y. H. Yun, Biocompatibility determination of novel L-tyrosine-based polyphosphates and polyurethanes, BioOhio, (2007). Winner of the best poster competition in best presentation of information.

Y. Cai, Y. H. Yun, and B. Z. Newby, Protein/Cell Adhesion on Gradient Surfaces of Poly(ethylene glycol) Generated by the Contact Printing Approach, Adhesion Society, (2007).

T. R. Williams, D. H. Reneker, D. J. Smith, G. Njus, and Y. H. Yun, Nano-structured Electrospun DNA Delivering Scaffolds for Gene Therapy Wound Healing Applications, Maurice Morton Institute of Polymer Science Sponsors Day Program, University of Akron, (2006). Winner of the Best Poster Competition.

P. N. Shah, S. T. Lopina, Y. H. Yun, Development of a microparticle type system for the controlled delivery of proteins using a novel L-tyrosine based biodegradable polyphosphate, International Society for Pharmaceutical Engineers, Annual Meeting, (2006). This poster has automatically accepted for the national meeting because it was the Winner of the Best Poster Competition for the Great Lakes chapter.


 
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